L-165041 | PPAR Receptors | Potent PPARd Agonist | L165041

Category:

Cat.No.	Product Name
1856	L-165,041

Price and Availability

Click here for full price details of
L-165041

Chemical Name: [4-[3-(4-Acetyl-3-hydroxy-2-propylphenoxy)propoxy]pheno xy]acetic acid

Biological Activity:

Potent PPARδ agonist (K_i = 6 nM); displays > 100-fold selectivity for both mouse and human PPARδ receptors over other subtypes. In vivo, raises plasma cholesterol levels in insulin-resistant db/db mice and is neuroprotective in models of cerebral infarction and Parkinson's disease.

Technical Data:

M.Wt:	402.44
Formula:	C₂₂H₂₆O₇
Storage:	Desiccate at RT
Solubility:	Soluble to 100 mM in 1eq. NaOH and to 100 mM in DMSO
Purity:	>98%
CAS No:	[79558-09-1]

Resources:

Certificate of Analysis / MSDS:

Certificate of Analysis: View current batch

For specific/earlier batch please select:

Product/Material Safety Data Sheet: View current batch

For specific/earlier batch please select:

References:

Berger et al (1999) Novel peroxisome proliferator-activated receptor (PPAR)γ and PPARδ ligands produce distinct biological effects. J.Biol.Chem. 274 6718. Leibowitz et al (2000) Activation of PPARδ alters lipid metabolism in db/db mice. FEBS Lett. 473 333. Iwashita et al (2007) Neuroprotective efficacy of the peroxisome proliferator-activated receptor δ-selective agonists in vitro and in vivo. J.Pharmacol.Exp.Ther. 320 1087.

View related products by Pharmacological Action or by Research Area

Keywords: L-165041, PPAR Receptors, Potent PPARd Agonist, L165041, Tocris Bioscience

New Product Guide

	Our latest New Product Guide highlights over 140 new products.
Request Copy / View PDF

Unique & Diverse Compound Libraries

Tocriscreen Collections : For pricing and compound information click here

Fully annotated small molecule libraries for HTS, HCS and
chemical biology applications.

1120 compounds
Pre-dissolved in DMSO

Tocriscreen Total (250 μL/well)
Tocriscreen Mini (50 μL/well)

New Products in this Area

Check back soon!
We are currently working on new products for this area

User ID
Password