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Category:
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7TM Receptors Peptides (Neuropeptides)NPY Receptors
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Cat.No.
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Product Name
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1382 |
L-152,804
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Price and Availability
Click here for full price details of
L-152,804
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Chemical Name:
5,5-Dimethyl-2-(2,3,4,9-tetrahydro-3,3-dimethyl-1oxo-1H
-xanthen-9-yl)-1,3-cyclohexanedione |
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Biological Activity:
Potent, selective non-peptide neuropeptide Y Y5
receptor antagonist (Ki = 26 nM for hY5). Displays >
300-fold selectivity over hY1, hY2, and hY4
receptors. Causes weight loss in diet-induced obese mice by modulating food
intake and energy expenditure. Centrally active upon
oral administration in vivo.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Kanatani et al (2000) L-152,804: orally active and selective
neuropeptide Y Y5 receptor antagonist. Biochem.Biophys.Res.Comm. 272
169. Schroeder et al (2005) The neuropeptide-Y Y5 receptor
antagonist L-152,804 decreases alcohol self-administration in inbred
alcohol-preferring (iP) rats. Alcohol 36 179. Mashiko et
al (2007) A pair-feeding study reveals that a Y5 antagonist causes weight
loss in diet-induced obese mice by modulating food intake and energy
expenditure. Mol.Pharmacol. 71 602.
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Keywords: L-152,804, Peptides (Neuropeptides), Potent, Selective Non-peptide NPY Y5 Antagonist, L152,804, Tocris Bioscience
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