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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowGlutamate (Ionotropic) ReceptorsarrowNon-Selective Ionotropic Glutamate
Cat.No. Product Name
0223

Kynurenic acid  

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Kynurenic acid
Chemical Name: 4-Hydroxyquinoline-2-carboxylic acid

Biological Activity:

Broad spectrum EAA antagonist.

Technical Data:

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M.Wt: 189.17
Formula: C10H7NO3
Storage: Store at RT
Solubility: Soluble to 75 mM in DMSO and to 100 mM in 1eq. NaOH
Purity: >98%
CAS No: [492-27-3]

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    References:

    Perkins and Stone (1982) An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid. Brain Res. 247 184. Stone and Burton (1988) NMDA receptors and ligands in the vertebrate CNS. Progr.Neurobiol. 30 333. Pittaluga et al (1997) The 'kynurenate test,' a biochemical assay for putative cognition enhancers. J.Pharmacol.Exp.Ther. 283 82.
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    Keywords: Kynurenic Acid, Ligand-gated Ion Channels, Broad Spectrum EAA Antagonist, Tocris Bioscience
    Literature in this Area
    Scientific Reviews
    The Ins & outs of Glutamate Transporter Pharmacology
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    Signal Transduction Guide
    Signal Transduction Guide : An informative guide for all scientists working in: Cell cycle & apoptosis, Protein kinases & phosphatases, Ion channels, Calcium & lipid signaling, Cyclic nucleotides & G-proteins, Nitric oxide, & Signaling EnzymesA complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes.
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    “Our laboratory loves dealing with Tocris and consider many of the compounds you sell to be far better quality than the compounds that we have received from other companies. Once again, thank you very much..”
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