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Category:
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Enzymes ProteasesOther Proteases
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Cat.No.
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Product Name
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2790 |
K 579
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Price and Availability
Click here for full price details of
K 579
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Chemical Name:
(2S)-1-[[[4-Methyl-1-(2-pyrimidinyl)-4-piperidinyl]amin
o]acetyl]-2-pyrrolidinecarbonitrile |
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Biological Activity:
Dipeptidyl peptidase IV inhibitor. Inhibits rat,
canine, human and monkey enzymes with IC50 values of 3, 5 8, and 8
nM respectively. Long-acting hypoglycaemic agent; attenuates glucose excursion
following glucose loading in Zucker fatty rats.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Takasaki et al
(2004) K579, a slow-binding inhibitor of dipeptidyl peptidase IV, is a
long-acting hypoglycemic agent. Eur.J.Pharmacol. 486 335. Takasaki
et al (2004) Effects of combination treatment with dipeptidyl peptidase
IV inhibitor and sulfonylurea on glucose levels in rats. J.Pharmacol.Sci. 95
291. Takasaki et al (2004) Involvement of the active metabolites
in the inhibitory activity of K579 on rat plasma dipeptidyl peptidase IV.
Eur.J.Pharmacol. 505 237.
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or by Research Area
Keywords: K 579, Proteases, Dipeptidyl Peptidase IV (DPP-IV) Inhibitor, K579, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
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