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Category: EnzymesarrowKinasesarrowProtein Kinase G
Cat.No. Product Name
1289 KT 5823
Price and Availability

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KT 5823
Chemical Name: (9S, 10R, 12R)-2,3,9,10,11,12-Hexahydro-10-methoxy-2,9-dimethyl-1 -oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrol o[3,4-i][1,6]benzodiazocine-10-carboxylic acid, methyl ester

Biological Activity:

Selective inhibitor of protein kinase G (Ki values are 0.23, 4 and > 10 μM for inhibition of PKG, PKC and PKA respectively). Inhibits SNP-stimulated PKG activity with an IC50 of 60 nM in dispersed smooth muscle cells and has little effect on PKA activity at concentrations of up to 10 μM.

Technical Data:

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M.Wt: 495.53
Formula: C29H25N3O5
Storage: Desiccate at -20°C
Solubility: Soluble to 50 mM in DMSO
CAS No: [126643-37-6]

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    • Certificate of Analysis / MSDS:

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    References:

    Gadbois et al (1992) Multiple kinase arrest points in the G1 phase of nontransformed mammalian cells are absent in transformed cells. Proc.Natl.Acad.Sci.USA 89 8626. Murthy and Makhlouf (1995) Interaction of cA-kinase and cG-kinase in mediating relaxation of dispersed smooth muscle cells. Am.J.Physiol. 268 C171. Smolenski et al (1998) Functional analysis of cGMP-dependent protein kinases I and II as mediators of NO/cGMP effects. Naunyn-Schmied.Arch.Pharmacol. 358 134.
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    Keywords: KT 5823, Kinases, Selective Protein Kinase G Inhibitor, KT5823, Tocris Bioscience
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