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Category: EnzymesarrowKinasesarrowProtein Kinase A
Cat.No. Product Name
1288 KT 5720
Price and Availability

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KT 5720
Chemical Name: (9R,10S,12S)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-meth yl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]py rrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, hexyl ester

Biological Activity:

Potent, selective inhibitor of protein kinase A (Ki = 60 nM). Has no effect on PKG or PKC (Ki > 2 μM). Reversibly arrests human skin fibroblasts in the G1 phase.

Technical Data:

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M.Wt: 537.61
Formula: C32H31N3O5
Storage: Desiccate at -20°C
Solubility: Soluble to 50 mM in DMSO
Purity: >98%
CAS No: [108068-98-0]

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    References:

    Kase et al (1987) K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases. Biochem.Biophys.Res.Comm. 142 436. Gadbois et al (1992) Multiple kinase arrest points in the G1 phase of nontransformed mammalian cells are absent in transformed cells. Proc.Natl.Acad.Sci.USA 89 8626. Cabell et al (1993) Effects of selective inhibition of protein kinase C, cyclicAMP-dependent protein kinase, and Ca(2+)-calmodulin-dependent protein kinase on neurite development in cultured rat hippocampal neurons. Int.J.Dev. Neurosci. 11 357.
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    Keywords: KT 5720, Kinases, Selective Protein Kinase A Inhibitor, KT5720, Tocris Bioscience
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