KN-93 | Signal Transduction | CaM Kinase II Inhibitor. Also K+ Channel Blocker (KV) | KN93

Category:

Cellular Processes and Components

Signal Transduction

Calcium Signalling

Calcium Binding Protein Modulators

Cat.No.	Product Name
1278	KN-93

Price and Availability

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KN-93

Other Information:

Not for sale in Japan

Chemical Name: N-[2-[[[3-(4-Chlorophenyl)-2-propenyl]methylamino]methy l]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulphonami de

Biological Activity:

Potent inhibitor of CaM kinase II (IC₅₀= 0.37 μM). Also a direct extracellular open channel blocker of voltage-gated potassium channels (IC₅₀ = 307 nM for Kv1.5); independent of CaM kinase II inhibition.

Technical Data:

M.Wt:	501.04
Formula:	C₂₆H₂₉ClN₂O₄S
Storage:	Store at +4°C
Solubility:	Soluble to 100 mM in DMSO
Purity:	>98%
CAS No:	[139298-40-1]

Resources:

Certificate of Analysis / MSDS:

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References:

Sumi et al (1991) The newly synthesized selective Ca²⁺/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine content in PC12h cells. Biochem.Biophys.Res.Comm. 181 968. Rezazadeh et al (2006) KN-93 (2-[N-(2-Hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]-amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), a calcium/calmodulin-dependent protein kinase II inhibitor, is a direct extracellular blocker of voltage-gated potassium channels. J.Pharmacol.Exp.Ther. 317 292. Anderson et al (1998) KN-93, an inhibitor of multifunctional Ca²⁺/calmodulin-dependent protein kinase, decreases early afterdepolarizations in rabbit heart. J.Pharmacol.Exp.Ther. 287 996.

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Keywords: KN-93, Signal Transduction, CaM Kinase II Inhibitor. Also K+ Channel Blocker (KV), KN93, Tocris Bioscience

Literature in this Area

Scientific Reviews

Mechanisms for Manipulating Intracellular Calcium Buffering
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