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Chemical Name:(6aR,10aR)-3-(1,1-Dimethylbutyl)-6a,7,10,10a-tetrahydro
-6,6,9-trimethyl-6H-dibenzo[b,d]pyran
Biological Activity:
Potent CB2 selective agonist (Ki = 3.4 nM).
Approx. 200-fold selective over CB1 receptors. Active in vivo,
reducing spasticity in a murine model of multiple sclerosis. Also available in
water soluble emulsion (Cat. No. 1783).
Huffmanet al (1999) 3-(1'-Dimethylbutyl)-1-deoxy-D8-THC and related compounds: synthesis of selective ligands for the
CB2 receptor. Bioorg.Med.Chem. 7 2905. Pertwee
(1999) Pharmacology of cannabinoid receptor ligands. Curr.Med.Chem. 6
635. Bakeret al (2000) Cannabinoids control spasticity and
tremor in a multiple sclerosis model. Nature 404 84.
Highly selective CB2 receptor agonist; Ki values are 0.037 and 363 nM for CB2 and CB1 receptors respectively. Increases P-ERK1/2 expression in HL-60 cells in vitro.
