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Category:
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7TM Receptors Cannabinoid ReceptorsCB2 Receptors
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Cat.No.
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Product Name
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2479 |
JTE 907
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Price and Availability
Click here for full price details of
JTE 907
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Chemical Name:
N-(1,3-Benzodioxol-5-ylmethyl)-1,2-dihydro-7-methoxy-2-
oxo-8-(pentyloxy)-3-quinolinecarboxamide |
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Biological Activity:
Highly selective cannabinoid CB2
receptor inverse agonist. Binds with high affinity to rat, mouse and human CB2
receptors (Ki values are 0.38, 1.55 and 35.9 nM respectively).
Produces anti-inflammatory effects in vivo.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Iwamura et
al (2001) In vitro and in vivo pharmacological characterization of JTE-907,
a novel selective ligand for cannabinoid CB2 receptor.
J.Pharmacol.Exp.Ther. 296 420. Ueda et al (2005)
Involvement of cannabinoid CB2 receptor-mediated response and
efficacy of cannabinoid CB2 receptor inverse agonist, JTE 907, in
cutaneous inflammation in mice. Eur.J.Pharmacol. 520 164.
Maekawa et al (2006) The cannabinoid CB2 receptor inverse
agonist JTE-907 suppresses spontaneous itch-associated responses of NC mice, a
model of atopic dermatitis. Eur.J.Pharmacol. 542 179.
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Keywords: JTE 907, Cannabinoid Receptors, Selective CB2 Receptor Antagonist / Inverse Agonist, JTE907, Tocris Bioscience
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