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Category:
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Ion Channels Calcium ChannelsVoltage-gated Calcium Channels
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Cat.No.
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Product Name
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2004 |
Isradipine
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| Alternative name(s): |
PN 200-110 |
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Price and Availability
Click here for full price details of
Isradipine
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Chemical Name:
4-(2,1,3-Benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-3
,5-pyridinecarboxylic acid methyl 1-methylethyl ester |
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Biological Activity:
Potent and selective L-type voltage-gated Ca2+ channel
blocker. EC50 and pA2 values are 1.4 nM and 10.3 for
relaxation of depolarisation- and Ca2+-induced contractions of
rabbit aorta respectively; EC25 = 0.45 nM for reduction in rate of
spontaneously beating guinea pig right atria. Long-acting antihypertensive
agent in vivo, exerting primary effects on vascular tissue with secondary
negative chronotropic action.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Hof et al (1984) PN 200-110, a new calcium antagonist:
electrophysiological, inotropic, and chronotropic effects on guinea pig
myocardial tissue and effects on contraction and calcium uptake of rabbit
aorta. J.Cardiovasc.Pharmacol. 6 399. Wada et al (1985)
Separation of the coronary vasodilator from the cardiac effects of PN 200-110,
a new dihydropyridine calcium antagonist, in the dog heart.
J.Cardiovasc.Pharmacol. 7 190. Ruegg and Hof (1990)
Pharmacology of the calcium antagonist isradipine. Drugs 40 3.
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View related products by Pharmacological Action
or by Research Area
Keywords: Isradipine, Calcium Channels, Ca2+ Channel Blocker (L-type), PN 200-110, Tocris Bioscience
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Literature in this Area Scientific Reviews
Mechanisms for Manipulating Intracellular Calcium Buffering Download PDF Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
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