5-Iodoresiniferatoxin | Transient Receptor Potential Channels | Potent, Silent TRPV1 (VR1) Antagonist | Iodoresiniferatoxin | 5-IRTX | 5Iodoresiniferatoxin

Category:

Ion Channels

Transient Receptor Potential Channels

TRPV

Cat.No.

Product Name

1362

5'-Iodoresiniferatoxin

Alternative name(s):	Iodoresiniferatoxin
	5'-IRTX

Price and Availability

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5-Iodoresiniferatoxin

Other Information:

Not for sale in the UK, France, Germany or Switzerland

Chemical Name: 6,7-Deepoxy-6,7-didehydro-5-deoxy-21-dephenyl-21-(pheny lmethyl)-daphnetoxin,20-(4-hydroxy-5-iodo-3-methoxybenz eneacetate)

Biological Activity:

Potent and silent vanilloid receptor antagonist, 40-fold more potent than capsazepine. Binds to TRPV1 (VR1) receptors expressed in HEK293 cells with a K_i of 5.8 nM.

Technical Data:

M.Wt:	754.6
Formula:	C₃₇H₃₉IO₉
Storage:	Desiccate at -20°C
Solubility:	Soluble in DMSO and to 100 mM in Ethanol
Purity:	>98%

Resources:

Certificate of Analysis / MSDS:

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References:

Wahl et al (2000) Iodo-resiniferatoxin, a new potent vanilloid receptor antagonist. Mol.Pharmacol. 59 9. Seabrook et al (2001) Properties of iodo-resiniferatoxin - a high affinity VR1 vanilloid receptor antagonist. Soc.Neurosci.Abstr. 925.9. Marinelli et al (2002) Capsaicin activation of glutamatergic synaptic transmission in the rat locus coeruleus in vitro. J.Physiol. 543 531.

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Keywords: 5-Iodoresiniferatoxin, Transient Receptor Potential Channels, Potent, Silent TRPV1 (VR1) Antagonist, Iodoresiniferatoxin, 5-IRTX, 5Iodoresiniferatoxin, Tocris Bioscience

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