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Category:
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Cellular Processes and Components Signal TransductionInositol and cAMP SignallingInositol Lipids
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Cat.No.
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Product Name
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1420 |
D-myo-Inositol-1,3,4,5-tetrakisphosphate, octapotassium salt
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Price and Availability
Click here for full price details of
D-myo-Inositol-1,3,4,5-tetrakisphosphate, octapotassium salt
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Biological Activity:
Phosphorylation
product of inositol 1,4,5-trisphosphate (Ins (1,4,5)P3). Potent
inhibitor of Ins (1,4,5)P3 5-phosphatase
(IC50 ~150 nM); facilitates Ca2+ influx by sensitising
Ins (1,4,5)P3-mediated activation of ICRAC. At higher concentrations, acts as an
inhibitor of Ins (1,4,5)P3 receptors.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Balla et al
(1991) Agonist-induced calcium signaling is impaired in fibroblasts
overproducing inositol 1,3,4,5-tetrakisphosphate. J.Biol.Chem. 266
24719. Cullen et al (1998) Bridging the GAP in inositol
1,3,4,5-tetrakisphosphate signalling. Biochim.Biophys.Acta 1436
35. Hermosura et al (2000) InsP4
facilitates store-operated calcium influx by inhibition of InsP3
5-phosphatase. Nature 408 735.
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or by Research Area
Keywords: D-myo-Inositol-1,3,4,5-tetrakisphosphate, Octapotassium Salt, Signal Transduction, Potent Inhibitor Of Ins(1,4,5)P3 5-phosphatase. Metabolite Of Cat. No. 1482, Dmyo-Inositol-1,3,4,5-tetrakisphosphate, Octapotassium Salt, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
Product Feature
cMet Signalling
Key cMet signalling compounds available from Tocris include:
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