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Category:
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7TM Receptors Histamine ReceptorsH3 and H4 ReceptorsAntagonists
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Cat.No.
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Product Name
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1858 |
Impentamine dihydrobromide
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VUF 4702 |
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Price and Availability
Click here for full price details of
Impentamine 2HBr
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Chemical Name:
4-(5-Aminopentyl)imidazole dihydrobromide |
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Biological Activity:
Potent and highly selective histamine H3
receptor antagonist (pA2 = 8.4); displays > 30000-fold
selectivity over H1 and H2 receptors. Can act as a
partial agonist in SK-N-MC cells expressing human H3 receptors.
Produces antinociception, possibly via a non-H1, -H2 or
-H3 receptor-mediated mechanism, following central administration in
vivo.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Vollinga et al (1995) Homologs of
histamine as histamine H3 receptor antagonists: a new potent and
selective H3 antagonist, 4(5)-(5-aminopentyl)-1H-imidazole.
J.Med.Chem. 38 266. Hough et al (1999)
Antinociceptive activity of impentamine, a histamine congener, after CNS
administration. Life Sci. 64 PL79. Wieland et al (2001)
Constitutive activity of histamine H3 receptors stably expressed in
SK-N-MC cells: display of agonism and inverse agonism by H3
antagonists. J.Pharmacol.Exp.Ther. 299 908.
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Keywords: Impentamine 2HBr, Histamine Receptors, Selective H3 Antagonist, VUF 4702, Tocris Bioscience
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