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Imetit dihydrobromide
Chemical Name:5-[2-(Imidazol-4-yl)ethyl]isothiourea dihydrobromide
Biological Activity:
An extremely potent, high affinity agonist at H3 and H4
receptors (Ki values are 0.3 and 2.7 nM respectively). Induces shape
change in eosinophils with an EC50 of 25 nM. Centrally active
following systemic administration.
Garbarget al (1992) S-[2-(4-Imidazolyl)ethyl]isothiourea, a highly
specific and potent histamine H3 receptor agonist.
J.Pharmacol.Exp.Ther. 263 304. Farzin and Attarzadeh
(2000) Influence of different histamine receptor agonists and antagonists on
apomorphine-induced licking behavior in rats. Eur.J.Pharmacol. 404
169. Linget al (2004) Histamine H4 receptor mediates
eosinophil chemotaxis with cell shape change and adhesion molecule
upregulation. Br.J.Pharmacol. 142 161.
