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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowGlutamate (Ionotropic) ReceptorsarrowNMDA SelectivearrowPolyamine SitearrowAntagonists
Cat.No. Product Name
0545 Ifenprodil hemitartrate  
Price and Availability

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Ifenprodil
Chemical Name: (1R*,2S*)-erythro-2-(4-Benzylpiperidino)-1-(4-hydroxyph enyl)-1-propanol hemitartrate

Biological Activity:

NMDA receptor antagonist, acting at the polyamine site. Also an α-adrenergic vasodilator. σ2 ligand displaying about 3-fold selectivity over σ1 sites.

Technical Data:

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M.Wt: 400.49
Formula: C21H27NO2.½C4H6O6
Storage: Store at RT
Solubility: Soluble to 15 mM in Water
Purity: >99%
CAS No: [23210-56-2]

Resources:

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    References:

    Gotti et al (1988) Ifenprodil and SL-82,0715 as cerebral anti-ischemic agents. 1. Evidence for efficacy in models of focal cerebral ischemia. J.Pharmacol.Exp.Ther. 247 1211. Reynolds and Miller (1989) Ifenprodil is a novel type of N-methyl-D-aspartate receptor antagonist:  interaction with polyamines. Mol.Pharmacol. 36 758. Schoemaker et al (1990) Polyamine-sensitive binding of [3H]ifenprodil, a novel NMDA antagonist to the rat cerebral cortex. Eur.J.Pharmacol. 183 1670. Shalaby et al (1992) Neuroprotective effects of the N-methyl-D-aspartate receptor antagonists ifenprodil and SL-82,0715 on hippocampal cells in culture. J.Pharmacol.Exp.Ther. 260 925.
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    Keywords: Ifenprodil, Ligand-gated Ion Channels, Non-competitive NMDA Antagonist. Also S Ligand, Tocris Bioscience
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