Idazoxan hydrochloride

Alternative name(s):

RX 781094

Idazoxan hydrochloride
C11H12N2O2.HCl 2-(1,4-Benzodioxan-2-yl)-2-imidazoline hydrochloride

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Idazoxan hydrochloride

Chemical Name: 2-(1,4-Benzodioxan-2-yl)-2-imidazoline hydrochloride

Biological Activity:

α₂-adrenoceptor antagonist, and I₂ ligand, selective over I₁ sites (pK_i values are 5.90, 7.22, 8.01, 7.43, and 7.7 for I₁, I₂, α_2A, α_2B, and α_2C receptors respectively).

Technical Data:

M.Wt:	240.69
Formula:	C₁₁H₁₂N₂O₂.HCl
Storage:	Store at RT
Solubility:	Soluble to 100 mM in Water
Purity:	>98%
CAS No:	[79944-56-2]

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Certificate of Analysis / MSDS:

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References:

Dabire (1986) Idazoxan: a novel pharmacological tool for the study of α₂-adrenoceptors. J.Pharmacol. 17 113. Michel and Ernsberger (1992) Keeping an eye on the I site: imidazoline-preferring receptors. TIPS 13 369. Dabire (1986) Idazoxan: a novel pharmacological tool for the study of α₂-adrenoceptors. J.Pharmacol. 17 113. Michel and Ernsberger (1992) Keeping an eye on the I site: imidazoline-preferring receptors. TIPS 13 369. Berdeu et al (1995) Evidence for two different imidazoline sites on pancreatic B cells and vascular bed in rat. Eur.J.Pharmacol. 275 91. Eglen et al (1998) 'Seeing through a glass darkly': casting light on imidazoline 'I' sites. TiPS 19 381.

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Keywords: Idazoxan Hydrochloride, Adrenergic Receptors, A2 Antagonist, I2 Ligand, RX 781094, Tocris Bioscience

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Adrenoceptor Pharmacology
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