ITE | Aryl Hydrocarbon Receptor | Endogenous Agonist For The Transcription Factor Aryl Hydrocarbon Receptor | Aryl Hydrocarbon Receptor Ligand

Category:

Nuclear Receptors

Aryl Hydrocarbon Receptor

Cat.No.

Product Name

1803

ITE

Alternative name(s):

Aryl hydrocarbon receptor ligand

ITE C14H10N2O3S 2-(1H-Indol-3-ylcarbonyl)-4-thiazolecarboxylic acid methyl ester

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ITE

Other Information:

Sold under licence, US Patent Application 2002183524

Chemical Name: 2-(1H-Indol-3-ylcarbonyl)-4-thiazolecarboxylic acid methyl ester

Biological Activity:

Endogenous agonist for the transcription factor aryl hydrocarbon receptor (AHR); K_i = 3 nM for binding to murine AHR. Transactivates DRE-containing reporter gene constructs in Hepa1c1c7 cells ~ 5-fold more potently than β-naphthoflavone. Active in vivo.

Technical Data:

M.Wt:	286.3
Formula:	C₁₄H₁₀N₂O₃S
Storage:	Store at RT
Solubility:	Soluble to 100 mM in DMSO
Purity:	>98%
CAS No:	[448906-42-1]

Resources:

Certificate of Analysis / MSDS:

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References:

Song et al (2002) A ligand for the aryl hydrocarbon receptor isolated from lung. Proc.Natl.Acad.Sci.USA 99 14694. Henry et al (2006) A potential endogenous ligand for the aryl hydrocarbon receptor has potent agonist activity in vitro and in vivo. Arch.Biochem.Biophys. 450 67.

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Keywords: ITE, Aryl Hydrocarbon Receptor, Endogenous Agonist For The Transcription Factor Aryl Hydrocarbon Receptor, Aryl Hydrocarbon Receptor Ligand, Tocris Bioscience

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