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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowGlutamate (Ionotropic) ReceptorsarrowAMPA SelectivearrowAntagonists
Cat.No. Product Name
1636 IEM 1460
Price and Availability

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IEM 1460
Chemical Name: N,N,N,-Trimethyl-5-[(tricyclo[3.3.1.13,7]dec-1-ylmethyl )amino]-1-pentanaminiumbromide hydrobromide

Biological Activity:

Voltage-dependent open-channel blocker of AMPA receptors. Displays selectivity between subtypes, blocking GluR2 subunit-lacking (Ca2+-permeable) receptors more potently than GluR2-containing receptors (IC50 values are 2.6 and 1102 μM respectively). Also blocks NMDA receptor-mediated currents. Anticonvulsant in vivo.

Technical Data:

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M.Wt: 454.33
Formula: C19H37N2Br.HBr
Storage: Desiccate at RT
Solubility: Soluble to 100 mM in Water
CAS No: [121034-89-7]

Resources:

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    • Certificate of Analysis / MSDS:

    Certificate of Analysis: View current batch
    Product/Material Safety Data Sheet: View current batch

    References:

    Magazanik et al (1997) Block of open channels of recombinant AMPA receptors and native AMPA/kainate receptors by adamantane derivatives. J.Physiol. 505 655. Buldakova et al (1999) Characterization of AMPA receptor populations in rat brain cells by the use of subunit-specific open channel blocking drug, IEM-1460. Brain Res. 846 52. Schlesinger et al (2005) Two mechanisms of action of the adamantane derivative IEM-1460 at human AMPA-type glutamate receptors. Br.J.Pharmacol. 145 656.
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    Keywords: IEM 1460, Ligand-gated Ion Channels, Open-channel Blocker Of AMPA Currents; Selective For Non-GluR2-containing Receptors, IEM1460, Tocris Bioscience
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