IDRA 21 | Ligand-gated Ion Channels | Inhibits AMPA Receptor Desensitisation | IDRA 21

Category:

Ion Channels

Ligand-gated Ion Channels

Glutamate (Ionotropic) Receptors

AMPA / Kainate Selective

Desensitization Modulators

Cat.No.	Product Name
1219	IDRA 21

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IDRA 21

Chemical Name: 7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazin e S,S-dioxide

Biological Activity:

Inhibits AMPA receptor desensitisation and enhances cognition by a related mechanism. More able to cross the blood-brain barrier than cyclothiazide (Cat. No. 0713).

Technical Data:

M.Wt:	232.68
Formula:	C₈H₉ClN₂O₂S
Storage:	Store at RT
Solubility:	Soluble to 100 mM in DMSO
Purity:	>98%
CAS No:	[22503-72-6]

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References:

Zivkovic et al (1995) 7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide (IDRA 21): a benzothiadiazine derivative that enhances cognition by attenuating DL-α-amino-2,3-dihydro-5-methyl-3-oxo-4-isoxazolepropanoic acid (AMPA) receptor desensitization. J.Pharmacol.Exp.Ther. 272 300. Thompson et al (1995) 7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide (IDRA 21), a congener of aniracetam, potently abates pharmacologically induced cognitive impairments in patas monkeys. Proc.Natl.Acad.Sci.USA 92 7667. Impagnatiello et al (1997) 7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide: a partial modulator of AMPA receptor desensitization devoid of neurotoxicity. Proc.Natl.Acad.Sci.USA 94 7053.

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Keywords: IDRA 21, Ligand-gated Ion Channels, Inhibits AMPA Receptor Desensitisation, IDRA 21, Tocris Bioscience

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