ICI 199,441 Hydrochloride | Opioid Receptors | Potent K Agonist | ICI199,441 Hydrochloride

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Cat.No.	Product Name
0778	ICI 199,441 hydrochloride

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ICI 199,441 hydrochloride

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Sold with the permission of AstraZeneca UK Ltd.

Chemical Name: 2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-phenyl-2-(1-p yrrolidinyl)ethyl]acetamide hydrochloride

Biological Activity:

Highly potent κ agonist, 146-fold more active than U-50488 (Cat. No. 0495) in vitro.

Technical Data:

M.Wt:	427.8
Formula:	C₂₁H₂₄Cl₂N₂O.HCl
Storage:	Store at RT
Solubility:	Soluble to 100 mM in DMSO and to 50 mM in Ethanol
Purity:	>99%
CAS No:	[115199-84-3]

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References:

Barlow et al (1991) Structure/activity studies related to 2-(3,4-dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)-1-substituted-ethyl]acetamides: a novel series of potent and selective κ-opioid agonists. J.Med.Chem. 34 3149. Costello et al (1991) 2-(3,4-Dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)-1-substituted-ethyl]acetamides: the use of conformational analysis in the development of a novel series of potent opioid κ agonists. J.Med.Chem. 34 181.

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Keywords: ICI 199,441 Hydrochloride, Opioid Receptors, Potent K Agonist, ICI199,441 Hydrochloride, Tocris Bioscience

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Opioid Receptors
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