No more than 100 mg per customer per year
to be sold
Chemical Name:7a,17b-[9-[(4,4,5,5,5-Pentafluoropentyl)sulfinyl]nonyl]
estra-1,3,5(10)-triene-3,17-diol
Biological Activity:
A high affinity estrogen receptor antagonist (IC50 =
0.29 nM), devoid of any partial agonism both in vitro and in vivo. Also high
affinity ligand at the membrane estrogen receptor GPR30.
Wakelinget al (1991) A potent specific pure antiestrogen with
clinical potential. Cancer Res. 51 3867. de Cupiset al
(1995) Comparison between novel steroid-like and conventional nonsteroidal
antioestrogens in inhibiting oestradiol and IGF-I induced proliferation of
human breast cancer-derived cells. Br.J.Pharmacol. 116 2391.Howellet al (2000) ICI 182,780
(FaslodexTM): Development of a novel, "pure" antiestrogen.
Cancer 89 817. Thomaset al (2005) Identity of an
estrogen membrane receptor coupled to a G protein in human breast cancer cells.
Endocrinol. 146 624.
