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Category:
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Other Activities Sigma and ImidazolineSigma LigandsSigma1
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Cat.No.
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Product Name
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0748 |
4-IBP
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Price and Availability
Click here for full price details of
4-IBP
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Chemical Name:
N-(N-Benzylpiperidin-4-yl)-4-iodobenzamide |
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Biological Activity:
Combines high affinity for σ1 and moderate affinity
for σ2 sites. Centrally active
following systemic administration in vivo.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
Certificate of Analysis is currently unavailable on-line. Please contact Customer Service
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References:
John et al (1994) Synthesis and characterisation of
[125I]-N-(N-benzylpiperidin-4-yl)-4-iodobenzamide, a new σ
receptor radiopharmaceutical: high affinity binding to MCF-7 breast tumor
cells. J.Med.Chem. 37 1737. Whittemore et al (1997)
Antagonism of N-methyl-D-aspartate receptors by σ site ligands: potency,
subtype-selectivity and mechanisms of inhibition. J.Pharmacol.Exp.Ther. 282
326.
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References:
Bermack
and Debonnel (2001)
Modulation of serotonergic neurotransmission by short- and long-term treatments
with sigma ligands. Br.J.Pharmacol. 134 691.
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View related products by Pharmacological Action
or by Research Area
Keywords: 4-IBP, Sigma & Imidazoline, S Ligand, S1 > S2, 4IBP, Tocris Bioscience
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