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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowGABAA and GABAC ReceptorsarrowMiscellaneous GABA
Cat.No. Product Name
0538 trans-4-Hydroxycrotonic acid  
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trans-4-Hydroxycrotonic acid
Chemical Name: trans-4-Hydroxy-2-butenoic acid

Biological Activity:

Binds to the γ-hydroxybutyric acid (GHB) receptor with higher affinity than GHB itself.  May be an endogenous ligand.

Technical Data:

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M.Wt: 102.09
Formula: C4H6O3
Storage: Desiccate at +4°C
Solubility: Soluble in Water
CAS No: [24587-49-3]

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    • Certificate of Analysis / MSDS:

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    Product/Material Safety Data Sheet: View current batch

    References:

    Vayer et al (1985) Natural occurrence of trans-gamma hydroxycrotonic acid in rat brain. Biochem.Pharmacol. 34 2401. Bourguignon et al (1993) Analogues of γ-hydroxybutyric acid.  Synthesis and binding studies. J.Med.Chem. 31 893. Hechler et al (1993) Gamma hydroxybutyrate ligands posses antidopaminergic and neuroleptic-like activities. J.Pharmacol.Exp.Ther. 264 1406.
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    Keywords: trans-4-Hydroxycrotonic Acid, Ligand-gated Ion Channels, GHB Receptor Ligand, 4Hydroxycrotonic Acid, Tocris Bioscience
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