L-(-)-threo-3-Hydroxyaspartic Acid | Neurotransmitter Transporters | Transportable EAAT1-4 Inhibitor / Non-transportable EAAT5 Inhibitor | L-threo-b-Hydroxyaspartic Acid | Lthreo-3-Hydroxyaspartic Acid

Category:

Transporters

Neurotransmitter Transporters

Glutamate Transporters

Cat.No.

Product Name

0183

L-(-)-threo-3-Hydroxyaspartic acid

Alternative name(s):

L-threo-b-Hydroxyaspartic acid

L-(-)-threo-3-Hydroxyaspartic acid
C4H7NO5

Price and Availability

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L-(-)-threo-3-Hydroxyaspartic acid

Biological Activity:

Potent, competitive, transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor.

Technical Data:

M.Wt:	149.1
Formula:	C₄H₇NO₅
Storage:	Store at RT
Solubility:	Soluble to 100 mM in 1eq. NaOH
CAS No:	[7298-99-9]

Resources:

Certificate of Analysis / MSDS:

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References:

Johnston et al (1980) Potentiation of L-glutamate and L-aspartate excitation of cat spinal neurones by the stereoisomers of threo-3-hydroxyaspartate. J.Neurochem. 34 241. McBean and Roberts (1985) Neurotoxicity of L-glutamate and DL-threo-3-hydroxyaspartate in the rat striatum. J.Neurochem. 44 247. Nakamura et al (1993) (2S,3S,4R)-2-(carboxycyclopropyl)glycine, a potent and competitive inhibitor of both glial and neuronal uptake of glutamate. Neuropharmacolgy 32 833.

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Keywords: L-(-)-threo-3-Hydroxyaspartic Acid, Neurotransmitter Transporters, Transportable EAAT1-4 Inhibitor / Non-transportable EAAT5 Inhibitor, L-threo-b-Hydroxyaspartic Acid, Lthreo-3-Hydroxyaspartic Acid, Tocris Bioscience

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