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Category: 7TM Receptorsarrow5-HT Receptorsarrow5-HT1 Receptorsarrow5-HT1A
Cat.No. Product Name
1080 (R)-(+)-8-Hydroxy-DPAT hydrobromide
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(R)-(+)-8-Hydroxy-DPAT hydrobromide
Chemical Name: (2R)-(+)-8-Hydroxy-2-(di-n-propylamino)tetralin hydrobromide

Biological Activity:

Full 5-HT1A serotonin receptor agonist; more active enantiomer. Reduces hippocampal 5-HT levels following systemic administration in rats in vivo.

Technical Data:

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M.Wt: 328.29
Formula: C16H25NO.HBr
Storage: Desiccate at +4°C
Solubility: Soluble to 75 mM in Water
CAS No: [80300-09-0]

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    References:

    Bjork et al (1989) Resolved N,N-dialkylated 2-amino-8-hydroxytetralins: stereoselective interactions with 5-HT1A receptors in the brain. J.Med.Chem. 32 779. Corrfield et al (1991) Intrinsic activity of enantiomers of 8-hydroxy-2-(di-n-propylamino)tetralin and its analogues at 5-hydroxytryptamine1A receptors that are negatively coupled to adenylate cyclase. Mol.Pharmacol. 39 780. Yoshitake and Kehr (2004) Differential effects of (R)-, (R, S)- and (S)-8-hydroxy-2-(di-n-propylamino)tetralin on hippocampal serotonin release and induction of hypothermia in awake rats. Life Sci. 74 2865.
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    Keywords: (R)-(+)-8-Hydroxy-DPAT Hydrobromide, 5-HT Receptors, More Active Enantiomer, 8Hydroxy-DPAT Hydrobromide, Tocris Bioscience
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