Glycyl-H-1152 | Kinases | More Selective Analogue Of Cat. No. 2414

Category:

Cat.No.	Product Name
2485	Glycyl-H 1152 dihydrochloride

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Glycyl-H-1152

Chemical Name: (S)-(+)-4-Glycyl-2-methyl-1-[(4-methyl-5-isoquinolinyl) sulfonyl]-hexahydro-1H-1,4-diazepine dihydrochloride

Biological Activity:

Glycyl analogue of the Rho-kinase inhibitor H 1152 dihydrochloride (Cat. No. 2414) that displays improved ROCKII selectivity. IC₅₀ values are 0.0118, 2.35, 2.57, 3.26, > 10 and >10 μM for ROCKII, Aurora A, CAMKII, PKG, PKA and PKC respectively.

Technical Data:

M.Wt:	449.4
Formula:	C₁₈H₂₄N₄O₃S.2HCl
Storage:	Desiccate at +4°C
Solubility:	Soluble to 100 mM in Water and to 50 mM in DMSO
Purity:	>99%

Resources:

Certificate of Analysis / MSDS:

Certificate of Analysis: View current batch

Product/Material Safety Data Sheet: View current batch

References:

Tamura et al (2005) Development of specific Rho-kinase inhibitors and their clinical application. Biochim.Biophys.Acta 1754 245.

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Keywords: Glycyl-H-1152, Kinases, More Selective Analogue Of Cat. No. 2414, Tocris Bioscience

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