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Category:
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7TM Receptors Peptides (Hypothalamic/Pituitary Hormones)Melanocortin Receptors
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Biological Activity:
Highly
potent melanocortin MC4 receptor antagonist (Ki values are 0.29,
18.6, 5.45 and 3.29 nM for cloned human MC4, MC1, MC3 and MC5 receptors
respectively). Increases food intake, and blocks α-MSH- and MTII-induced hypotension
and bradycardia in rats, following central administration in vivo.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
Certificate of Analysis is currently unavailable on-line. Please contact Customer Service
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References:
Kask et al (1998) Discovery of a
novel superpotent and selective melanocortin-4 receptor antagonist (HS024):
evaluation in vitro and in vivo. Endocrinology 139
5006. Jonsson et al (2001) Melanocortin receptor agonist
transiently increases oxygen consumption in rats. Neuroreport 12
3703. Jonsson et al (2002) Food conversion is transiently
affected during 4-week chronic administration of melanocortin agonist and
antagonist in rats. J.Endocrinol. 173 517.
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View related products by Pharmacological Action
or by Research Area
Keywords: HS 024, Peptides (Hypothalamic / Pituitary Hormones), Highly Potent MC4 Receptor Antagonist, HS024, Tocris Bioscience
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