HS 014 | Peptides (Hypothalamic / Pituitary Hormones) | Selective MC4 Receptor Antagonist | HS014

Category:

Peptides (Hypothalamic/Pituitary Hormones)

Cat.No.	Product Name
1831	HS 014

Price and Availability

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HS 014

Biological Activity:

Potent and selective melanocortin MC4 receptor antagonist (K_i values are 3.16, 108, 54.4 and 694 nM for cloned human MC4, MC1, MC3 and MC5 receptors respectively). Increases food intake in rats and nociception in mice following central administration in vivo.

Technical Data:

M.Wt:	1563.77
Formula:	C₇₁H₉₄N₂₀O₁₇S₂
Storage:	Desiccate at -20°C
CAS No:	[207678-81-7]

Resources:

Certificate of Analysis / MSDS:

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Product/Material Safety Data Sheet: View current batch

References:

Schioth et al (1998) Discovery of novel melanocortin₄ receptor selective MSH analogues. Br.J.Pharmacol. 124 75. Kask et al (1998) Selective antagonist for the melanocortin 4 receptor (HS014) increases food intake in free-feeding rats. Biochem.Biophys.Res.Comm. 245 90. Bellasio et al (2003) Melanocortin receptor agonists and antagonists modulate nociceptive sensitivity in the mouse formalin test. Eur.J.Pharmacol. 482 127.

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Keywords: HS 014, Peptides (Hypothalamic / Pituitary Hormones), Selective MC4 Receptor Antagonist, HS014, Tocris Bioscience

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