HOE 140 | Peptides (Cardiovascular) | Potent & Selective B2 Antagonist | Icatibant | HOE140

Category:

7TM Receptors

Peptides (Cardiovascular)

Bradykinin Receptors

Cat.No.

Product Name

3014

HOE 140

Alternative name(s):

Icatibant

Price and Availability

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HOE 140

Biological Activity:

Potent and selective bradykinin B₂ receptor antagonist (pA₂ = 9.04). Also inhibits aminopeptidase N (K_i = 9.1 μM).

Technical Data:

M.Wt:	1304.52
Formula:	_{C59H89N19O13S}
Storage:	Store at -20°C
CAS No:	[138614-30-9]

Resources:

Certificate of Analysis / MSDS:

Certificate of Analysis: View current batch

Product/Material Safety Data Sheet: View current batch

References:

Hock et al (1991) Hoe 140 a new potent and long acting bradykinin-antagonist: in vitro studies. Br.J.Pharmacol. 102 769. Feletou et al (1994) Agonistic and antagonistic properties of the bradykinin B₂ receptor antagonist, Hoe 140, in isolated blood vessels from different species. Br.J.Pharmacol. 112 683. Bawolak et al (2006) The bradykinin B₂ receptor antagonist icatibant (Hoe 140) blocks aminopeptidase N at micromolar concentrations: off-target alterations of signaling mediated by the bradykinin B₁ and angiotensin receptors. Eur.J.Pharmacol. 551 108.

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Keywords: HOE 140, Peptides (Cardiovascular), Potent & Selective B2 Antagonist, Icatibant, HOE140, Tocris Bioscience

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