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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowGlutamate (Ionotropic) ReceptorsarrowNMDA SelectivearrowGlycine SitearrowAntagonists
Cat.No. Product Name
0282

(S)-(-)-HA-966  

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(S)-(-)-HA-966
Chemical Name: (S)-(-)-3-Amino-1-hydroxypyrrolidin-2-one

Biological Activity:

Possesses potent sedative and ataxic action, probably through disruption of striatal dopaminergic mechanisms.

Technical Data:

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M.Wt: 116.12
Formula: C4H8N2O2
Storage: Store at RT
Solubility: Soluble to 100 mM in Water
Purity: >98%
CAS No: [111821-58-0]

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    References:

    Singh et al (1990) Enantiomers of HA-966 (3-amino-1-hydroxypyrrolidin-2-one) exhibit distinct central nervous system effects: (+)-HA-966 is a selective glycine/N-methyl-D-aspartate receptor antagonist, but (-)-HA966 is a potent γ-butyrolactone-like sedative. Proc.Natl.Acad.Sci.USA 87 347. Shepard and Lehmann (1992) (±)-1-Hydroxy-3-aminopyrrolidone-2 (HA-966) inhibits the activity of substantia nigra dopamine neurons through a non-N-methyl-D-aspartate receptor mediated mechanism. J.Pharmacol.Exp.Ther. 261 387. Grobaski et al (1997) Responses of rat substantia nigra dopamine-containing  neurones to (-)-HA-966 in vitro. Br.J.Pharmacol. 120 575.
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    Keywords: (S)-(-)-HA-966, Ligand-gated Ion Channels, NMDA Antagonist / Partial Agonist, HA966, Tocris Bioscience
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