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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowGlutamate (Ionotropic) ReceptorsarrowNMDA SelectivearrowGlycine SitearrowAgonists
Cat.No. Product Name
0281

(R)-(+)-HA-966  

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(R)-(+)-HA-966

Other Information:

Sold with the permission of Merck Sharp and Dohme Ltd
Chemical Name: (R)-(+)-3-Amino-1-hydroxypyrrolidin-2-one

Biological Activity:

Antagonist/partial agonist at the glycine site of the NMDA receptor; able to cross the blood-brain barrier.

Technical Data:

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M.Wt: 116.12
Formula: C4H8N2O2
Storage: Desiccate at RT
Solubility: Soluble to 100 mM in Water
Purity: >98%
CAS No: [123931-04-4]

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    References:

    Pullan et al (1990) Stereoselectivity for the (R)-enantiomer of HA-966 (1-hydroxy-3-aminopyrrolidone-2) at the glycine site of the N-methyl-D-aspartate receptor complex. J.Neurochem. 55 1346. Kemp and Priestley (1991) Effects of (+)-HA-966 and 7-chlorokynurenic acid on the kinetics of N-methyl-D-aspartate receptor agonist responses in cat cultured cortical neurons. Mol.Pharmacol. 39 666. Pullan et al (1991) Agonist-like character of the (R) enantiomer of 1-hydroxy-3-amino-pyrrolid-2-one (HA-966). Eur.J.Pharmacol. 208 25.
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    Keywords: (R)-(+)-HA-966, Ligand-gated Ion Channels, Partial NMDA Agonist, Acts Glycine Site, HA966, Tocris Bioscience
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