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Category: TransportersarrowNeurotransmitter TransportersarrowGABA Transporters
Cat.No. Product Name
0234

Guvacine hydrochloride  

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Guvacine hydrochloride
Chemical Name: 1,2,5,6-Tetrahydropyridine-3-carboxylic acid hydrochloride

Biological Activity:

Specific GABA uptake inhibitor. IC50 values are 14, 58, 119 and 1870 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively.

Technical Data:

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M.Wt: 163.6
Formula: C6H9NO2.HCl
Storage: Store at RT
Solubility: Soluble to 100 mM in Water
Purity: >99%
CAS No: [498-96-4]

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    References:

    Krogsgaard-Larsen et al (1978) Structure-activity studies on the inhibition of GABA binding to rat brain membranes by muscimol and related compounds. J.Neurochem. 30 1377. Borden et al (1994) Tiagabine, SK&F 89976-A, CI 966, and NNC-711 are selective for the cloned GABA transporter GAT-1. Eur.J.Pharmacol. 269 219.
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    Keywords: Guvacine Hydrochloride, Neurotransmitter Transporters, Specific GABA Uptake Inhibitor, Tocris Bioscience

    Literature in this Area
    Scientific Reviews
    GABA Receptors
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    Our laboratory loves dealing with Tocris and consider many of the compounds you sell to be far better quality than the compounds that we have received from other companies. Once again, thank you very much..”
    Researcher, Albany Medical College, USA
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