Guanfacine Hydrochloride | Adrenergic Receptors | A2A Agonist

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Cat.No.	Product Name
1030	Guanfacine hydrochloride

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Guanfacine hydrochloride

Chemical Name: [(2,6-Dichlorophenyl)acetyl]guanidine hydrochloride

Biological Activity:

Selective α_2A-adrenoceptor agonist (K_d = 31 nM). Displays 60-fold selectivity over α_2B-adrenoceptors.

Technical Data:

M.Wt:	282.56
Formula:	C₉H₉Cl₂N₃O.HCl
Storage:	Store at RT
Solubility:	Soluble to 100 mM in Water and to 100 mM in DMSO
Purity:	>99%
CAS No:	[29110-48-3]

Resources:

Certificate of Analysis / MSDS:

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References:

Merck Index 12 4590. Uhlen and Wikberg (1991) Delineation of rat kidney α_2A- and α_2B-adrenoceptors with [³H]RX821002 radioligand binding: computer modelling reveals that guanfacine is an α_2A-selective compound. Eur.J.Pharmacol. 202 235. Intengan and Smyth (1997) Alpha-2a/d adrenoceptor subtype stimulation by guanfacine increases osmolar clearance. J.Pharmacol.Exp.Ther. 281 48.

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Keywords: Guanfacine Hydrochloride, Adrenergic Receptors, A2A Agonist, Tocris Bioscience

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Adrenoceptor Pharmacology
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