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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowGlutamate (Ionotropic) ReceptorsarrowNMDA SelectivearrowGlycine SitearrowAgonists
Cat.No. Product Name
0219

Glycine  

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Glycine
Chemical Name: Aminoethanoic acid

Biological Activity:

One of the major inhibitory neurotransmitters in the mammalian CNS, predominantly active in the spinal cord and brain stem. Also acts as a modulator of excitatory amino acid transmission mediated by NMDA receptors.

Technical Data:

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M.Wt: 75.07
Formula: C2H5NO2
Storage: Store at RT
Solubility: Soluble to 100 mM in Water
CAS No: [56-40-6]

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    References:

    Johnson and Ascher (1987) Glycine potentiates the NMDA response in cultured mouse brain neurons. Nature (Lond.) 325 529. Ascher and Johnson (1989) The NMDA receptor, its channel and its modulation by glycine. In The NMDA Receptor. Eds. J.C. Watkins and G.L. Collingridge, p 109, IRL Press, Oxford. Betz (1991) Glycine receptors: heterogeneous and widespread in the mammalian brain. TiNS 10 113. Kuhse et al (1995) The inhibitory glycine receptor: architecture, synaptic localization and molecular pathology of a postsynaptic ion-channel complex. Curr.Opinion.Neurobiol. 5 318.
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    Keywords: Glycine, Ligand-gated Ion Channels, Endogenous Potentiator, Co-transmitter, Tocris Bioscience
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