Click here for full price details of Glucagon-like peptide 1 (7-36) amide
Biological Activity:
Potent glucose-dependent insulinotropic peptide
produced by post-translational processing of proglucagon in intestinal L-cells.
Displays high affinity for GLP-1 receptors expressed in rat insulinoma-derived
RINm5F cells (Kd = 204 pM). Stimulates insulin gene transcription
and secretion in pancreatic β-cells.
Displays antiapoptotic effects in hippocampal neurons and reduces food intake
in fasted rats following central administration.
Goke
and Conlon (1988)
Receptors for glucagon-like peptide-1(7-37) amide on rat insulinoma-derived
cells. J.Endocrinol. 116 357. Turtonet al (1996) A
role for glucagon-like peptide-1 in the central regulation of feeding. Nature 379
69. Perfetti andMerkel (2000) Glucagon-like peptide-1: a major
regulator of pancreatic β-cell function. Eur.J.Endocrinol. 143 717. Perryet
al (2002) Protection and reversal of excitotoxic neuronal damage by
glucagon-like peptide-1 and exendin-4. J.Pharmacol.Exp.Ther. 302
881.
