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Category:
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7TM Receptors Peptides (Gastrointestinal)Glucagon and Related Peptide ReceptorsGlucagon-Like Peptide 1 Receptors
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Cat.No.
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Product Name
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1851 |
Glucagon-like peptide 1 (1-37) (human, bovine, guinea pig, mouse, rat)
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GLP-1
(1-37) amide |
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Price and Availability
Click here for full price details of
Glucagon-like peptide 1 (1-37)
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Biological Activity:
Pancreatic
hormone synthesised by post-translational processing of proglucagon. Unlike
truncated forms of GLP-1, it has no effect on food intake in rats and does not
enhance pancreatic insulin secretion. However it induces insulin expression in
intestinal epithelial cells, which can restore glucose homeostasis when
implanted into diabetic mice.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
Certificate of Analysis is currently unavailable on-line. Please contact Customer Service
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References:
Bell et al (1983) Exon duplication
and divergence in the human preproglucagon gene. Nature 304 368. Navarro
et al (1996) Colocalization of glucagon-like peptide-1 (GLP-1)
receptors, glucose transporter GLUT-2, and glucokinase mRNAs in rat
hypothalamic cells: evidence for a role of GLP-1 receptor agonists as an
inhibitory signal for food and water intake. J.Neurochem. 67
1982. Suzuki et al (2003) Glucagon-like peptide 1 (1-37) converts
intestinal epithelial cells into insulin-producing cells.
Proc.Natl.Acad.Sci.USA 100 5034.
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Keywords: Glucagon-like Peptide 1 (1-37), Peptides (Gastrointestinal), Endogenous Pancreatic Peptide, GLP-1 (1-37) Amide, Tocris Bioscience
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