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Category:
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7TM Receptors PAF Receptors
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Cat.No.
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Product Name
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1657 |
Ginkgolide B
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| Alternative name(s): |
BN 52021 |
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Price and Availability
Click here for full price details of
Ginkgolide B
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Chemical Name:
(1R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11R,11aR)-3-(1,1-Dime
thylethyl)hexahydro-4,7b,11-trihydroxy-8-methyl-9H-1,7a
-(epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3',
2':3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione |
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Biological Activity:
Platelet-activating
factor (PAF) receptor antagonist (Ki = 1.3 μM). Inhibits neutrophil degranulation
and superoxide production in vitro and inhibits bronchoconstriction and is
neuroprotective following oral administration in vivo.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Desquand
et al (1986) Interference of BN 52021
(ginkgolide B) with the bronchopulmonary effects of PAF-acether in the
guinea-pig. Eur.J.Pharmacol. 127 83. Foldes-Filep et al
(1987) Inhibition by BN 52021 (ginkgolide B) of the binding of [3H]-platelet-activating
factor to human neutrophil granulocytes. Biochem.Biophys.Res.Comm. 148
1412. Maclennan et al (2002) The CNS effects of Ginkgo biloba
extracts and ginkgolide B. Prog.Neurobiol. 67 235.
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or by Research Area
Keywords: Ginkgolide B, PAF Receptors, PAF Receptor Antagonist, BN 52021, Tocris Bioscience
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