Peptide derived from connexin 43 that is a
selective gap junction blocker. Attenuates ACh-induced arterial relaxation and
reduces K+-mediated smooth muscle repolarisation in
endothelium-intact vessels in vitro.
Chaytoret al
(1998) Central role of heterocellular gap junctional communication in
endothelium-dependent relaxations of rabbit arteries. J.Physiol. 508
561. Koet al (2000) Biochemical and functional characterization
of intercellular adhesion and gap junctions in fibroblasts. Am.J.Physiol.Cell
Physiol. 279 C147. Richardset al (2001)
Suppression of K+-induced hyperpolarization by phenylephrine in rat
mesenteric artery: relevance to studies of endothelium-derived hyperpolarizing
factor. Br.J.Pharmacol. 134 1.
“Our laboratory loves dealing with Tocris and consider many of the compounds you sell to be far better quality than the compounds that we have received from other companies. Once again, thank you very much..”