Tocris Bioscience
Welcome to Tocris

| Advanced Search
Home Products Technical Support Customer Support Literature Custom Synthesis
Category: Cellular Processes and ComponentsarrowOther Signal TransductionarrowGap Channels
Cat.No. Product Name
1476 Gap 27
Price and Availability

Click here for full price details of
Gap 27

Biological Activity:

Peptide derived from connexin 43 that is a selective gap junction blocker. Attenuates ACh-induced arterial relaxation and reduces K+-mediated smooth muscle repolarisation in endothelium-intact vessels in vitro.

Technical Data:

Click here for more information on batch specific data
M.Wt: 1304.55
Formula: C60H101N15O17
Storage: Desiccate at -20°C
CAS No: [198284-64-9]

Resources:

  • Certificate of Analysis / MSDS:

    Certificate of Analysis: View current batch
    For specific/earlier batch please select:  
    Product/Material Safety Data Sheet: View current batch
    For specific/earlier batch please select:  

    References:

    Chaytor et al (1998) Central role of heterocellular gap junctional communication in endothelium-dependent relaxations of rabbit arteries. J.Physiol. 508 561. Ko et al (2000) Biochemical and functional characterization of intercellular adhesion and gap junctions in fibroblasts. Am.J.Physiol.Cell Physiol. 279 C147. Richards et al (2001) Suppression of K+-induced hyperpolarization by phenylephrine in rat mesenteric artery: relevance to studies of endothelium-derived hyperpolarizing factor. Br.J.Pharmacol. 134 1.
    View related products by Pharmacological Action or by Research Area

    Keywords: Gap 27, Other Signal Transduction, Selective Gap Junction Blocker, Gap27, Tocris Bioscience

    Literature in this Area
    Signal Transduction Guide
    Signal Transduction Guide : An informative guide for all scientists working in: Cell cycle & apoptosis, Protein kinases & phosphatases, Ion channels, Calcium & lipid signaling, Cyclic nucleotides & G-proteins, Nitric oxide, & Signaling EnzymesA complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes.
    View PDF
    Our laboratory loves dealing with Tocris and consider many of the compounds you sell to be far better quality than the compounds that we have received from other companies. Once again, thank you very much..”
    Researcher, Albany Medical College, USA
    New Products in this Area

     2839Levetiracetam
     Anti-epileptic; binds SV2A
     2585Compstatin
     C3-binding protein, inhibits complement activation
    Sign-up for new product e-alerts
    Log In / Register

    User ID
    Password
    If you are not registered with us Create Account