Galanthamine Hydrobromide | Ligand-gated Ion Channels | Cholinesterase Inhibitor | Galantamine

Category:

Ion Channels

Ligand-gated Ion Channels

Acetylcholine (Nicotinic) Receptors

Other Acetylcholine

Cat.No.

Product Name

0686

Galanthamine hydrobromide

Alternative name(s):

Galantamine

Galanthamine hydrobromide
C17H21NO3.HBr 4a,5,9,10,11,12-Hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol hydrobromide

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Galanthamine hydrobromide

Chemical Name: 4a,5,9,10,11,12-Hexahydro-3-methoxy-11-methyl-6H-benzof uro[3a,3,2-ef][2]benzazepin-6-ol hydrobromide

Biological Activity:

Long-acting, centrally active acetylcholinesterase inhibitor (IC₅₀ = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. Prevents β-amyloid-induced apoptosis in SH-SY5Y and bovine chromaffin cells. Long-term administration reduces amyloid precursor protein deposition and neurodegeneration in a mouse model of Alzheimer's disease.

Technical Data:

M.Wt:	368.27
Formula:	C₁₇H₂₁NO₃.HBr
Storage:	Store at RT
Solubility:	Soluble to 100 mM in DMSO and to 50 mM in Water
Purity:	>97%
CAS No:	[1953-04-4]

Resources:

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References:

Sweeney et al (1989) Galanthamine, an acetylcholinesterase inhibitor: a time course of the effects on performance and neurochemical parameters in mice. Pharmacol.Biochem.Behav. 34 129. Harvey (1995) The pharmacology of galanthamine and its analogues. Pharmacol.Ther. 68 113. Capsoni et al (2002) Nerve growth factor and galantamine ameliorate early signs of neurodegeneration in anti-nerve growth factor mice. Proc.Natl.Acad.Sci.USA 99 12432. Samochocki et al (2003) Galantamine is an allosterically potentiating ligand of neuronal nicotinic but not of muscarinic acetylcholine receptors. J.Pharmacol.Exp.Ther. 305 1024. Arias et al (2004) Galantamine prevents apoptosis induced by β-amyloid and thapsigargin: involvement of nicotinic acetycholine receptors. Neuropharmacology 46 103.

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Keywords: Galanthamine Hydrobromide, Ligand-gated Ion Channels, Cholinesterase Inhibitor , Galantamine, Tocris Bioscience

Literature in this Area

Scientific Reviews

Nicotinic ACh Receptors
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