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Galanin (1-15) (porcine, rat)
Biological Activity:
N-terminal galanin fragment. In contrast to the
full length (1-29) peptide, mediates central cardiovascular effects, perhaps by
binding to a novel receptor type.
Amiranoffet al
(1989) Structural requirements for galanin action in the pancreatic b cell line rin m 5F. Eur.J.Pharmacol.
163 205. Xuet al (1999) Electrophysiological
evidence for a hyperpolarizing, galanin (1-15)-selective receptor on
hippocampal CA3 pyramidal neurons. Proc.Natl.Acad.Sci.USA 96
14583. Narvaezet al (2000) The galanin receptor antagonist M40
blocks the central cardiovascular actions of the galanin N-terminal fragment
(1-15). Eur.J.Pharmacol. 399 197.