|
Category:
|
Nuclear Receptors LXR-like Receptors
|
|
Cat.No.
|
Product Name
|
|
2473 |
GW 4064
|
|
|
|
Price and Availability
Click here for full price details of
GW 4064
Other Information:
Sold for research purposes under agreement from
GlaxoSmithKline
|
|
Chemical Name:
3-[2-[2-Chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-methylet
hyl)-4-isoxazolyl]methoxy]phenyl]ethenyl]benzoic acid |
|
|
Biological Activity:
Selective,
nonsteroidal farnesoid X receptor (FXR) agonist (EC50 = 15 nM).
Displays no activity at other nuclear receptors at concentrations up to 1 μM. Improves hyperglycaemia and
hyperlipidaemia in diabetic db/db mice.
|
Technical Data:
|
|
|
Resources:
|
|
Certificate of Analysis / MSDS:
|
References:
Maloney et al (2000) Identification
of a chemical tool for the orphan nuclear receptor FXR. J.Med.Chem. 43
2971. Zhang et al (2006) Activation of the nuclear receptor FXR
improves hyperglycemia and hyperlipidemia in diabetic mice.
Proc.Natl.Acad.Sci.USA 103 1006. Cariou et al
(2006) The farnesoid X receptor modulates adiposity and peripheral insulin
sensitivity in mice. J.Biol.Chem. 281 11039.
|
|
View related products by Pharmacological Action
or by Research Area
Keywords: GW 4064, LXR-like Receptors, Selective Farnesoid X Receptor (FXR) Agonist, GW4064, Tocris Bioscience
|
