GW 1929 | PPAR Receptors | Selective PPARg Agonist. Orally Active | GW1929

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Cat.No.	Product Name
1664	GW 1929

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GW 1929

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Sold for research purposes under agreement from GlaxoSmithKline

Chemical Name: N-(2-Benzoylphenyl)-O-[2-(methyl-2-pyridinylamino)ethyl ]-L-tyrosine

Biological Activity:

Highly selective orally active peroxisome proliferator-activated receptor (PPAR)γ agonist (pEC₅₀ values are 8.05, < 4 and < 4 for human PPARγ, PPARα and PPARδ receptors respectively). Decreases glucose, fatty acid and triglyceride levels following oral administration in vivo.

Technical Data:

M.Wt:	532.03
Formula:	C₃₀H₂₉N₃O₄
Storage:	Desiccate at +4°C
Solubility:	Soluble to 100 mM in Ethanol and to 100 mM in DMSO
Purity:	>98%
CAS No:	[196808-24-9]

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References:

Brown et al (1999) A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-γ reverses the diabetic phenotype of the Zucker diabetic fatty rat. Diabetes 48 1415. Nugent et al (2001) Potentiation of glucose uptake in 3T3-L1 adipocytes by PPARγ agonists is maintained in cells expressing a PPARγ dominant-negative mutant: evidence for selectivity in the downstream responses to PPARγ activation. Mol.Endocrinol. 15 1729. Way et al (2001) Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor γ agonists. J.Biol.Chem. 276 25651.

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Keywords: GW 1929, PPAR Receptors, Selective PPARg Agonist. Orally Active, GW1929, Tocris Bioscience

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