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Category:
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Enzyme-Linked Receptors Receptor Tyrosine Kinases (RTKs)Other RTKs
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Cat.No.
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Product Name
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2086 |
GTP 14564
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Price and Availability
Click here for full price details of
GTP 14564
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Chemical Name:
3-Phenyl-1H-benzofuro[3,2-c]pyrazole |
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Biological Activity:
Potent,
selective inhibitor of class III receptor tyrosine kinases (IC50
values are 0.3 μM for c-Fms, c-Kit, FLT3 and ITD-FLT3
and 1 μM for PDGFRβ). Displays no selectivity for ERK1,
ERK2, EGFR, MEK1, HER2, Src, Abl, PKC, PKA and Akt (IC50 > 10 μM). Inhibits FL-dependent
proliferation in BaF/ITD-FLT3 cells more potently than BaF/wt-FLT3 cells;
anti-leukaemic.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
Certificate of Analysis is currently unavailable on-line. Please contact Customer Service
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References:
Murata et al (2003) Selective
cytotoxic mechanism of GTP-14564, a novel tyrosine kinase inhibitor in leukemia
cells expressing a constitutively active Fms-like tyrosine kinase 3 (FLT3).
J.Biol.Chem. 278 32892. Yao et al (2005) Human
leukemias with mutated FLT3 kinase are synergistically sensitive to FLT3 and
Hsp90 inhibitors: the key role of the STAT5 signal transduction pathway.
Leukemia 19 1605.
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View related products by Pharmacological Action
or by Research Area
Keywords: GTP 14564, Receptor Tyrosine Kinases (RTKs), Class III Receptor Tyrosine Kinase (RTK) Inhibitor, GTP14564, Tocris Bioscience
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Literature in this Area Cancer Research Guide | Our unique collection of more than 300 products related to cancer research, including the very latest exclusive research tools. | | Request Copy / View PDF |
Product Feature
Kinase Inhibitors
Key kinase Inhibitors available from Tocris include:
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