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Category:
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7TM Receptors Peptides (Neuropeptides)Tachykinin ReceptorsNK-2 Receptor
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Cat.No.
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Product Name
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1667 |
GR 94800
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Price and Availability
Click here for full price details of
GR 94800
Other Information:
Sold for
research purposes under agreement from GlaxoSmithKline
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Biological Activity:
Potent and selective tachykinin NK2 receptor antagonist
(pKB values are 9.6, 6.4 and 6.0 for NK2, NK1
and NK3 receptors respectively). Active in vivo.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
McElroy et al (1992) Highly potent and selective heptapeptide
antagonists of the neurokinin NK-2 receptor. J.Med.Chem. 35 2582.
Zagorodnyuk et al (1995) Evidence that tachykinin NK1
and NK2 receptors mediate non-adrenergic non-cholinergic excitation
and contraction in the circular muscle of guinea-pig duodenum. Br.J.Pharmacol. 115
237. Matuszek et al (1998) An investigation of tachykinin NK2
receptor subtypes in the rat. Eur.J.Pharmacol. 352 103.
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Keywords: GR 94800, Peptides (Neuropeptides), Potent, Selective NK2 Antagonist, GR94800, Tocris Bioscience
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