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Category: 7TM ReceptorsarrowOpioid ReceptorsarrowKappa ReceptorsarrowAgonists
Cat.No. Product Name
1483 GR 89696 fumarate
Price and Availability

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GR 89696
Chemical Name: 4-[(3,4-Dichlorophenyl)acetyl]-3-(1-pyrrolidinylmethyl) -1-piperazinecarboxylic acid methyl ester fumarate

Biological Activity:

Highly potent and selective κ-opioid agonist (IC50 = 0.04 nM) that may be selective for the putative κ2 receptor. Anti-nociceptive and neuroprotective in vivo.

Technical Data:

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M.Wt: 530.4
Formula: C19H25Cl2N3O3.C4H4O4
Storage: Store at RT
Solubility: Soluble to 25 mM in Water
Purity: >99%
CAS No: [126766-32-3]

Resources:

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    • Certificate of Analysis / MSDS:

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    Product/Material Safety Data Sheet: View current batch

    References:

    Birch et al (1991) Neuroprotective actions of GR89696, a highly potent and selective κ-opioid receptor agonist. Br.J.Pharmacol. 103 1819. Naylor et al (1993) A potent new class of κ-receptor agonist: 4-substituted 1-(arylacetyl)-2-[(dialkylamino)methyl]piperazines. J.Med.Chem. 36 2075. Butelman et al (2001) GR89,696: a potent κ-opioid agonist with subtype selectivity in rhesus monkeys. J.Pharmacol.Exp.Ther. 298 1049.
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    Keywords: GR 89696, Opioid Receptors, Subtype-selective K Opioid Agonist, GR89696, Tocris Bioscience
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