|
Category:
|
7TM Receptors Peptides (Neuropeptides)Tachykinin ReceptorsNK-2 Receptor
|
|
Cat.No.
|
Product Name
|
|
1668 |
GR 64349
|
|
|
|
Price and Availability
Click here for full price details of
GR 64349
Other Information:
Sold for
research purposes under agreement from GlaxoSmithKline
|
|
|
|
|
Biological Activity:
Potent
and selective tachykinin NK2 receptor agonist (EC50 = 3.7
nM in rat colon). Displays > 1000- and > 300-fold selectivity over NK1
and NK3 receptors respectively. Active in vivo.
|
Technical Data:
|
|
|
Resources:
|
|
Certificate of Analysis / MSDS:
|
References:
Deal et al (1992) Conformationally
constrained tachykinin analogues: potent and highly selective neurokinin NK-2
receptor agonists. J.Med.Chem. 35 4195. Chizh et al
(1995) Endogenous modulation of excitatory amino acid responsiveness by
tachykinin NK1 and NK2 receptors in the rat spinal cord.
Br.J.Pharmacol. 115 1013. Chang et al (2000)
Tachykinin receptor subtypes in the isolated guinea pig heart and their role in
mediating responses to neurokinin A. J.Pharmacol.Exp.Ther. 294
147.
|
|
View related products by Pharmacological Action
or by Research Area
Keywords: GR 64349, Peptides (Neuropeptides), Potent, Selective NK2 Agonist, GR64349, Tocris Bioscience
|
|
Dedicated Customer Service
At Tocris we understand that customer service means more than just taking orders, we are here to act in partnership with you and to help you further your research. We do our best to ensure that your purchasing experience at Tocris is quick and effortless.
We are committed to making sure that over 99% of our products are in stock and in every case Tocris provides same day shipping of orders. Our friendly and efficient team delivers top quality support time after time.
|
|
