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Other Information:
Sold with the permission of GlaxoSmithKline
Chemical Name:3-[3-(Dimethylamino)propyl]-4-hydroxy-N-[4-(4-pyridinyl
)phenyl]benzamide dihydrochloride
Biological Activity:
A selective competitive 5-HT1B
(5-HT1Dβ) silent antagonist with
pKB values of 7.3 and 6.3for human cloned 5-HT1B and 5-HT1D receptors
respectively and only weak binding at a number of other 5-HT subtypes.
Connoret al (1995) Use of GR55562, a selective 5-HT1D antagonist,
to investigate 5-HT1D receptor subtypes mediating cerebral
vasoconstriction. Cephalalgia 15 (suppl. 14) 99. Walshet
al (1995) The activity of 5-HT1D receptor ligands at cloned
human 5-HT1Dα and 5-HT1Dβ receptors. Eur.J.Pharmacol. 287 79. MacLeanet
al (1996) Evidence for 5-HT1-like receptor-mediated
vasoconstriction in human pulmonary artery. Br.J.Pharmacol. 119
277.
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