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GR 144053 trihydrochloride
Chemical Name:4-[4-[4-(Aminoiminomethyl)phenyl]-1-piperazinyl]-1-pipe
ridineacetic acid trihydrochloride
Biological Activity:
A potent and selective platelet fibrinogen receptor glycoprotein
IIb/IIIa (GpIIb/IIIa) antagonist (IC50 = 37 nM). Orally active and
highly effective at inhibiting thrombus formation in vivo.
Eldredet al (1994) Orally active non-peptide fibrinogen receptor
(GpIIb/IIIa) antagonists: identification of
4-[4-[4-(aminoiminomethyl)phenyl]-1-piperazinyl]-1-piperidineacetic acid as a
long-acting, broad spectrum antithrombotic agent. J.Med.Chem. 37
3882. Matsunoet al (1997) GR 144053, a fibrinogen receptor
antagonist, enhances the suppression of neointima formation by losartan, an
angiotensin II receptor antagonist, in the injured carotid artery of hamster.
Br.J.Pharmacol. 122 1099. Matsuno et al (1999)
Comparative antiplatelet effects of aspirin, vapiprost and GR 144053, a
GPIIb/IIIa antagonist with special reference to the role of platelet
microaggregates. Br.J.Pharmacol. 127 1129.
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