GBR 13069 Dihydrochloride | Neurotransmitter Transporters | Potent Dopamine Uptake Inhibitor | GBR13069 Dihydrochloride

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Cat.No.	Product Name
0420	GBR 13069 dihydrochloride

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GBR 13069 dihydrochloride

Chemical Name: (1-(2-(Bis-(4-fluorophenyl)methoxy)ethyl)-4-(3-phenyl-2 -propenyl)piperazine dihydrochloride

Biological Activity:

A potent inhibitor of dopamine uptake (IC₅₀ = 40 nM). Centrally active following systemic administration in vivo.

Technical Data:

M.Wt:	521.48
Formula:	C₂₈H₃₀F₂N₂O.2HCl
Storage:	Desiccate at RT
Solubility:	Soluble to 5 mM in Water
CAS No:	[77862-93-2]

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References:

Heikkila et al (1984) Behavioural properties of GBR12909, GBR13069 and GBR13098: specific inhibitors of dopamine uptake. Eur.J.Pharmacol. 103 241. Van der Zee and Hespe (1985) Interaction between substituted 1-[2-diphenylmethoxyethyl]piperazines and dopamine receptors. Neuropharmacology 24 1171. Mayer et al (1986) Prevention of the nigrostriatal toxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by inhibitors of 3,4-dihydroxyphenylethylamine transport. J.Neurochem. 47 1073.

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Keywords: GBR 13069 Dihydrochloride, Neurotransmitter Transporters, Potent Dopamine Uptake Inhibitor, GBR13069 Dihydrochloride, Tocris Bioscience

Literature in this Area

Scientific Reviews

Dopamine Receptors
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Product Feature

Uptake Inhibitors

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