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Category:
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Enzymes PhosphatasesPP
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Cat.No.
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Product Name
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1840 |
Fostriecin sodium salt
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Price and Availability
Click here for full price details of
Fostriecin
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Chemical Name:
(6R)-5,6-Dihydro-6-[(1E,3R,4R,6R,7Z,9Z,11E)-3,6,13-trih
ydroxy-3-methyl-4-(phosphonooxy)-1,7,9,11-tridecatetrae
nyl]-2H-pyran-2-one sodium salt |
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Biological Activity:
Originally identified as an anti-tumour
antibiotic from Streptomyces pulveraceous. Displays potent inhibition of
protein phosphatase types 2A (PP2A) and 4 (PP4) with IC50 values of
1.5 nM and 3 nM respectively. Also exhibits weaker inhibition of topoisomerase
II (IC50 = 40 μM) and
protein phosphatase type 1 (PP1) (IC50 = 131 μM) with no
apparent inhibition of protein phosphatase type 2B (PP2B). Active in vivo.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Tunac et al
(1983) Novel antitumor agents CI-920, PD 113,270 and PD 113,271. I. Taxonomy,
fermentation and biological properties. J.Antibiot. 36 1595. Walsh
et al (1997) Fostriecin, an antitumor antibiotic with inhibitory
activity against serine/threonine protein phosphatases types 1 (PP1) and 2A
(PP2A), is highly selective for PP2A. FEBS Lett. 416 230. Hastie
and Cohen (1998) Purification of protein phosphatase 4 catalytic subunit:
inhibition by the antitumour drug fostriecin and other tumour suppressors and promoters.
FEBS Lett. 431 357.
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Keywords: Fostriecin, Phosphatases, Potent PP2A & PP4 Inhibitor, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
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